Adenoviral Keratoconjunctivitis in Korea: Serotypes and Clinical Characteristics

Purpose: Human adenoviruses are a major cause of epidemic keratoconjunctivitis. Of over 60 genotypes, subgroup D is associated with There are, however, no data regarding the genotypes conjunctivitis-causing in Korea. The purpose this study was to determine types causing keratoconjunctivitis and clinical manifestations Korea.Methods: From November 2016 September 2017, 20 conjunctival swab specimens were collected from patients who clinically suspected have adenoviral Nucleic acids extracted using QIAamp Viral mini kit processed on QIAcube platform. Genotyping targeted for adenovirus capsid hexon genes performed by polymerase chain reaction sequencing techniques. Patient ages ranged 18 days 69 years (median, 37 years).Results: specimens, 17 (85.0%) genotyped. Three samples not amplified our primer sets. Eleven (64.7%) type 8, five (29.4%) 37, one 64. All genotyped showed injections (100%) follicles (100%), 12 (84.6%) pseudomembrane formation. In case most them corneal involvement cornea filamentary keratitis.Conclusions: This that direct effective techniques genotyping common causes Korea 8 period time. Conjunctival injection, follicle formation, formation infections.